Waleed Ragab Radwan Ragab El Beialy

Ragia Mounir

01/12/2018

open sinus lift is used to augment the maxillary sinus prior to implant Placement in patients with sinus pneumatization due to early extraction of upper molars Where the remaining available bone length is from zero to 6 mm which will not accommodate for implant placement and not sufficient for implant initial stability so we will need to do Sinus lift and augmentation of the sinus with various bone grafts either (alloplast, allograft, Autogenous). Search is conducted electronically on line in pub med & Cochrane and manual Search was also done from 2007 to 2018 the articles included assisting &evaluating various types of bone substitute used in open sinus lift surgeries.197 papers are identified through data base searching 37 Additional records identified through manual search, after duplication removal the remaining papers are 187,187 paper were reviewed&152 were excluded by title &abstract, 35 article were reviewed as full text, 27 articles were excluded by reason, 8 articles were included in this study, Eight included articles have revealed new bone formation with percentage ranges from 48%as the highest percentage&16.4 as the lowest percentage, residual material ranges from 6.3%to 34.8% which differs according to type of bone graft used, histological evaluation is performed in 7 articles in addition to radiological evaluation only one article used radiographic evaluation only This systematic review supported the fact that bone substitute act as a scaffold for new bone formation with different percentages according to type of bone substitute used.

Waleed Ragab Radwan Ragab El Beialy

01/01/2012

Assessment of marginal bone loss using full thickness versus partial thickness flaps for alveolar ridge splitting and immediate implant placement in the anterior maxilla

Waleed Ragab Radwan Ragab El Beialy

01/01/2010

Regulation of human and pig renal Na+,K+-ATPase activity by tyrosine phosphorylation of their ɑ1-subunits

Waleed Ragab Radwan Ragab El Beialy

01/01/2010

Abstract Proteomic and genomic studies commonly involve the assessment of mRNA levels using reverse transcription-polymerase chain reaction (PCR) and real-time quantitative PCR. An internal standard RNA is fundamentally analyzed along with the investigated mRNA to document the specificity of the effect(s) on mRNA and to correct for inter-sample variations. In our studies implementing estrogen treatments on different cell lines, we initially used glyceraldehyde-3-phosphate dehydrogenase (G3PDH) as an internal standard. However, the results of PCR amplification demonstrated that 17β-estradiol enhanced the expression of the G3PDH gene, rendering it impossible to use G3PDH as an unbiased comparative control.

Waleed Ragab Radwan Ragab El Beialy

01/01/2010

Abstract We investigated the possible roles of estrogen on plasma membrane Ca(2+)-ATPase (PMCA) in human fibroblast-like synovial cells (HFLS) and mouse macrophage-like cells (RAW 264.7). Western blots revealed the expression of PMCA 2 and 4 in both cells. In vitro treatments with 17beta-estradiol for 24 hours resulted in a concentration dependent decrease in PMCA expression. Moreover, Ca(2+)-ATPase specific activity was similarly decreased with estrogen treatments. However, treatments for 1 hour in the presence or absence of cycloheximide demonstrated non-significant effects. These results suggest that estrogen has a modulatory role on Ca(2+) homeostasis through decreasing PMCA expression and abating their activity.

Waleed Ragab Radwan Ragab El Beialy

01/01/2010

Reviewer

Waleed Ragab Radwan Ragab El Beialy

01/06/2008

Abstract Several epidemiological studies have reported that temporomandibular disorder is more prevalent in women, which suggests the involvement of sex hormones, such as estrogen, in the pathogenesis of this disease. PCR amplification and Western blotting were employed to target the expression of estrogen receptors (ERs) in human fibroblast-like synovial and ATDC5 cells. The effect of estrogen was investigated through the expression of RANKL, osteoprotegerin (OPG), M-CSF/CSF-1 and c-fms. We showed expression of M-CSF/ CSF-1 and c-fms, with time-dependent increase in both after the addition of estrogen. Based on previous studies reporting that M-CSF/CSF-1 regulates the proliferation and differentiation of hemopoietic progenitor cells into mature macrophages, we put forward a new hypothesis based on the increased inflammation and tendency of females to suffer more from temporomandibular disorder (TMD) in the presence of external exacerbating factors. Detection of RANKL and OPG in ATDC5 and expression of both in HFLS was confirmed with complete disappearance of the RANKL band, and marked increase in the expression of OPG after 1 h from the addition of estrogen.

Waleed Ragab Radwan Ragab El Beialy

01/01/2008

Enhancing chemosensitivty of oral squamous carcinomas by inorganic polyphosphate

Waleed Ragab Radwan Ragab El Beialy

01/07/2007

Abstract Temporomandibular disorder (TMD), a progressive disease entity, and osteoarthrosis preferentially affect females, denoting a possible role of estrogen. Using RAW 264.7 cells, the expression of estrogen receptors (ERs) alpha and beta and the consequent effect of estrogen was investigated. We present the novel detection of ER beta expression in RAW 264.7 cells. Furthermore, we innovatively demonstrated the increase in expression of both ER alpha and beta, as well as RANK and c-fms, with estrogen treatment. However, a decrease in expression of c-fms, RANK and ER beta, and nearly no change in the expression of ER alpha were experienced upon further increase in estrogen concentrations. These findings lead us to hypothesize a new mechanism of inflammation in TMD.